DNA Interactions of Polymerized Schiff Base Ligand and Its Complexes Obtained from Naringenin

Salih Paşa

Abstract


(4E)-4-[(2-{[(4E)-5,7-dihydroxy-3-(4-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-ylidene] aminoethyl)imino]-2-(4-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-5,7-diol (L1) ligand derived from naringenin and ethylenediamine was synthesized according to the literature (Yang and Li 2008). In addition Co(II) and Cu(II) metal complexes were obtained with monomer ligand of L1. Then it was polymerized by oxidative polycondensation reaction to get the poly-Schiff base ligand (L2). Cu(II) and Co(II) were characterized by elemental analyses, magnetic susceptibility, molar conductivity, UV-Vis, FT-IR and TGA/DTA. L2 was characterized UV-Vis., FT-IR, 1H NMR, TGA/DTA and GPC. Our aim was to examine the interaction of these compounds with DNA. For this purpose they were used for direct interaction with DNA and presence of H2O2 experiments; serious damage to DNA only the complex of L1Cu. In the presence of H2O2, L2 and L1Co compounds were significantly reduced the damage to DNA while L1Cu increased the damage of the DNA complex.

Keywords


DNA Interaction; poly Schiff base; oxidative polycondensation

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DOI: http://dx.doi.org/10.7212%2Fzkufbd.v7i2.774

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